DNP and Diabetes

[Zing9000]

Hey everyone. I'm a type 1 diabetic and I'm attempting to determine the effects of DNP on blood glucose levels in order to determine how I should change my insulin regimen should I decide to start using DNP.

My current regimen mimics a normal pancreas' function; I have 24 hour acting basal insulin doses, and 1 hour acting rapid doses which come in bolus after a meal.

From my research it would appear as though DNP would only affect the basal insulin dose required, drastically reducing it, but it is not entirely clear how the function of DNP acts during carbohydrate intake, which requires a correction in the amount of bolus insulin taken after a meal.

Concillator, this thread is mostly directed at you, since you seem to be the primary source of information regarding DNP. However, other bodybuilders who use insulin and DNP may also have useful opinions, as insulin is insulin, regardless of whether you're diabetic or not.

Furthermore, in order to achieve an optimal effect as a result of the DNP towards fatloss, what consistant blood glucose levels should be maintained? Naturally, they should be elevated slightly in order to make sure that I don't drop into hypoglycemia, but since I have the advantage of being able to precisely control my glucose levels at any time I want (give or take about 10 minutes for the rapid insulin to act, or for glucose to enter my system) I am attempting to determine whether having a slightly elevated glucose level throughout the day would be beneficial.

Any supplimentary information would be greatly appreciated.

[Zing9000]

Oh, I forgot to add, I have also found in my research that DNP may have been contemplated as an insulin suppliment in diabetics during the time of initial experimentation with the drug, which was about the same time that insulin was very difficult to come by, and basically unknown as to it's dosage, which is why it was highly ineffective at saving diabetics' lives during the '30s. But since I have the advantage of being able to closely monitor my glucose levels, I can basically tailor-make a DNP+insulin regimen to do whatever I please. I just need a bit more information about how it will affect glucose uptake so I can compensate.

[Conciliator]

If you have access to the research, take a look at Simkin's paper in JAMA. I'm pretty sure it was either June or July 1937. He looked at carbohydrate metabolism and found that there were no consistent changes when subjects took DNP for a short period of time. Some had increased glucose tolerance and others had decreased tolerance. The same was true with fasting glucose levels. They were higher in some diabetics and lower in just as many. Conversely, with long term DNP use (from three weeks to over a year) it appeared that there was an increase in carbohydrate tolerance, which Simkins proposed might have a possible application in treating diabetes. Of course, that was before insulin was available.

All in all, I wouldn't expect any big changes from a low or moderate dose of DNP.

[Zing9000]

I have taken a look at these articles, but I'm very wary of their credibility particularly at that time. Not only was insulin not available, but blood glucose testing of individuals with diabetes was certainly not at the state which it is today - that is to say, there was little understanding of where the levels should be on an hourly basis, it was simply assumed that if the HbA1C levels were higher or lower than the carbohydrate tolerance had changed. This is pretty inaccurate, and which is why we had diabetics back in those days going into comas when insulin did come because of massive overdoses, or going into comas because of hyperglycemia.

On top of this, it's not understood whether these are insulin dependant diabetics or not. There was no distinguishment between type 1 and type 2 diabetes back then, of which we have a very intimate understanding today. Naturally, type 1 is completely different in nature in comparison to type 2, where type 2 patients do have their own insulin.

This naturally brings me to a bit of a dilemma when it comes ot the expectations I should have for my own personal research regarding DNP use. If there is any other information available, it would be helpful, otherwise I believe I'll probably have to write a log and attached report for everybody to see the results. Since I take my blood glucose measurements a ridiculously pendantic amount of times a day, I have a very accurate reading as to where the levels should be, and where they are. Hopefully this should provide some very useful information for others, and should provide additional insight into what DNP actually does to your glucose levels in order to determine how insulin and other drugs can be used while on DNP or in combination with DNP.