DNP and hives

[nightcrew213]

My first run at DNP was excellent.I lost 9lbs in 10 days.It went as follows:
Day 1-3 200mg a day
Day 4-10 400mg a day
No sides at all.

My second run (2 weeks after) was horrible.The start of my 3rd day I broke out in hives all over my fingers.They were huge and yellow and itched like hell.I tried benedryl and it had no effect.I went to the Doc and told him I was clearing out some brush behind my garage and I touched some plants I had never seen before.He put me on Prednisone and in about 3 days the hives were gone.I also started the second run at 400mg a day.

My third run (6 weeks after) and WTF?The hives are starting to show up again around my finger tips.I started at 200mg a day,days 1-3 and now this again?
Should I try 200mg eod or just give up?I work with people all day and cant have my hands all blown out in hives.Maybe I should just try a T3/Clen/ECA stack instead?

Any help would be great.Thanks.

One of the coolest things about my first run was the bright yellow color of my cum shots My girl freaked out but oh well.

[2small]

I got hives too on DNP really bad though all over my body the Doc gave me prednisone as well it cleared up after couple days but that was the worst case of hives I had ever scene. They were all over. Heretic told me I probably need to take Benadryl before i even start the DNP for a day or two just to try and prevent it from happening again. But i have not done it since. My temp also went up close to 103. The hives are a side effect you can get and they dont have to happen on the first time.

[bg65]

take benadryl at night and claritin every day

[lolokoss]

Bump for H,

my guess is that you have become allergic to the stuff, but it's only a guess.
The first cycle would qualify as the sesitization phase, that's why you got no sides.

[Kayz]

Take 1 benadryl (25mg) ED before you go to bed (it will make you tired, so get plenty of rest) the entire time you are taking DNP.....and continue the benadryl for 1 week AFTER DNP intake stops. This should take care of your hives.

[Heretic]

What Kayz said. Some people are just really sensitive to the stuff, and even if you don't think you are you may find your second or third cycle that you get a rash/hives. It even happened to me, although I think it was from running two high dose cycles without enough time in between. IMO this is really only the serious side you may encounter from DNP because they are not fun AT ALL. What I do now is take 25mg Benadryl (one cap) each night before bed (it makes you sleepy) for 2 days prior to the cycle, each day during the cycle, and for a week afterward, and I haven't had a problem since. IF YOU WAIT UNTIL YOU ACTUALLY GET HIVES IT'S TOO LATE, YOU HAVE TO USE THE BENADRYL TO PREVENT IT, NOT CURE IT. By then you may as well go to the doc and make up some excuse so you can get some Prednisone, that shit will knock it on it's ass.
Regards,
-H-

[nightcrew213]

Thanks for the advice,much appreciated.

[progressive labs]

Originally Posted by Heretic

What Kayz said. Some people are just really sensitive to the stuff, and even if you don't think you are you may find your second or third cycle that you get a rash/hives. It even happened to me, although I think it was from running two high dose cycles without enough time in between. IMO this is really only the serious side you may encounter from DNP because they are not fun AT ALL. What I do now is take 25mg Benadryl (one cap) each night before bed (it makes you sleepy) for 2 days prior to the cycle, each day during the cycle, and for a week afterward, and I haven't had a problem since. IF YOU WAIT UNTIL YOU ACTUALLY GET HIVES IT'S TOO LATE, YOU HAVE TO USE THE BENADRYL TO PREVENT IT, NOT CURE IT. By then you may as well go to the doc and make up some excuse so you can get some Prednisone, that shit will knock it on it's ass.
Regards,
-H-

Me and two friends all broke out in hives day nine. freaked me out. Prednisone injection, pills, Allegra, and steriod cream worked in a jiffy. IMO the body can only take so much of it and I would rather show hives as an indication of taking too much too long rather than something more serious happening.

[Heretic]

It's not so much that you're taking too much DNP as that DNP causes a histamine build up in the body, and if it builds up too much then you get the rash/hives. I've never really heard a medical explanation for the phenomenon, but it can happen to some guys at 200mg ED. That's why I always recommend benadryl or claritin.
Regards,
-H-

[progressive labs]

Originally Posted by Heretic

It's not so much that you're taking too much DNP as that DNP causes a histamine build up in the body, and if it builds up too much then you get the rash/hives. I've never really heard a medical explanation for the phenomenon, but it can happen to some guys at 200mg ED. That's why I always recommend benadryl or claritin.
Regards,
-H-

The Histamine build up makes sense, thus taking an antihistamine to combat. But I take 3 benadryl everynight to help sleep for the last two years and I still got the hives? However, "H" I bump you for your help. Just wish I knew about this phenomena before I handed it out to my friends who couldn't go to work for two days.

[Heretic]

If you've been using benadryl that long I don't know how it would affect things, I would maybe try using claritin instead.
Regards,
-H-

[demeurj]

I developed the "Revenge of DNP" hive after my second cycle. The response is probably NOT a histamine buildup. Histamine (like most acute phase reactants) has a VERY short half-life. It's actually the interaction of DNP with your immune system that causes the problem.

DNP is a highly reactive molecule. But due to it's small size your immune system pretty much ignores it . . . that is until DNP begins attaching itself to larger molecules in the body. The fancy term is hapten. Anyway, once DNP is bound to larger molecules your immune system takes notice and mounts a vigorous response. In particular, it's called a delayed hypersensitivity reaction. That's the reason why people like myself still had symptoms 4 weeks after stopping DNP.

Benadryl (and most other antihistamines) help with the histamine but since your broader immune system is "kicking arse and taking names) . . . it's a losing battle. I tried Claritin (over the counter it's loratadine) but it was only a touch more effective than Benadryl (diphenhydramine). I finally broke down and went to my doctor. Naturally, I told the truth about what happened (I'm a doctor as well). Anyway, he disagreed with my treatment suggestion (prednisolone) and chose Zyrtec instead. It actually worked quite well (much better than Claritin or Benadryl) but I was on it daily for another two weeks.

Lessons:
1) Shorter cycles are better.
2) Lower doses are better.
3) Healthy intervals between cycles are better.
4) Pretreat with an antihistamine for at least a day or two . . . then use an antihistamine for the duration of your DNP cycle AND consider continued use for a period afterwards of at least 4 half-lives . . . personally I'm planning at least FIVE.

[Heretic]

That's the first time I've heard that. It's interesting though because the therapy is still the same as what I said, use an antihistmaine for a couple days before the cycle, during, and for a week afterward. Like I said I do that now and haven't had a single problem since then.
Regards,
-H-

[lolokoss]

Originally Posted by demeurj

Lessons:
1) Shorter cycles are better.
2) Lower doses are better.
3) Healthy intervals between cycles are better.
4) Pretreat with an antihistamine for at least a day or two . . . then use an antihistamine for the duration of your DNP cycle AND consider continued use for a period afterwards of at least 4 half-lives . . . personally I'm planning at least FIVE.

How short are these cycles we are talking about and what dosages?

[progressive labs]

Interesting...so however it is still agreed reducing the histamine levels can prevent the hives. I read on a new post recently that DNP may help areas of the immune system. I did well with Allegra and prednisone but due to the severity of this hives episode I am not through gathering more information. My one friend, a pharmacuetical rep, has not even spoken to me since I handed her the stuff. She went from drop dead gorgeous to deformed in about 12 hours on her 9th day, (her last day). Dealing in a highly professional job and doing a DNP cycle does not mix well. Looking for more info....