Of the limited information available on DNP that I've been able to locate, there are always suggestions that one should be taking antioxidants to offset the increased incidence of free radicals from the process. I also noticed that the suggestions for antioxidants were fairly random. Since the only long term/irreversable side effects from DNP are probably caused by free radicals, I found it curious that the antioxident regimen was somewhat pedantic.
For curiosity alone, I dug around to find what could be a targeted antioxident regimen for a DNP cycle. Here's what I came up with:
I.
In the early 1900's, with the absence of any set procedures in taking DNP, there was a 1% incidence of cataracts over a large population (over 100,000).
http://board1.mantisforums.com/uploa...?threadid=6871
Scientists have determined that the carotenoids lutein and zeaxanthin accumulate in the eyes, specifically in the lens and the macula (the area on the retina responsible for distinguishing fine details). This led them to speculate that people who consume a diet rich in these carotenoids may be less likely to develop cataracts or macular degeneration. http://www.healthandage.com/Home/gm=6!gid2=997
Carotenoids-
Astaxanthin
Canthaxanthin
Lutein
Zeaxanthin
beta-carotein
lycopene
apparently, Astaxanthin is slightly stronger than any of the rest (no reference)
II.
For some reason DNP use can cause a histamine build-up in the body, which means a rash/hives. This may not happen your first cycle, but if you use a lot or do not take enough time off inbetween for your body to process the remaining DNP, you may encounter this. [go to page 1, you'll find this
]
OPCs (oligomeric proanthrocyanidin complexes) reduce the release and production of pro-inflammatory histamine
OPCs:
grape seed extract (mostly procyanidins)
grape skin (anthocyanidins)
pine bark
camellia sinensis (found in green tea)
OPCs found in: hawthorn flowers, berries, onions, peas, parsley
related componds found in: bilberry, cranberry, uva ursi, coffee, chocolate, peanut skins
http://www.mcp.edu/herbal/opcs/opcs.pdf
III.
DNP accomplishes the astounding boost in metabolic rate via inhibition of the F0F1 ATP synthase molecule, located in the inner wall of each mitochondrion.
http://board1.mantisforums.com/uploa...?threadid=6871
In order to burn fats and carbohydrates to make metabolic fuel, mitochondria take electrons from oxygen and shuffle them among a suite of molecules in a complex chain reaction. Invariably, some of the electrons get misplaced, creating free radicals. "People have estimated that [the electron transport chain] is maybe 98 percent efficient, which is much better than a human engineer can do," says Ames. "But it still makes kilos of oxygen radicals per person per year."
Mitochondria produce more oxidants than any other single site in a cell, the main offenders being superoxide, hydrogen peroxide, and hydroxyl radicals. Ames thought mitochondria would therefore be hardest hit by free-radical damage, not only to mitochondrial DNA but also to enzymes in the electron transport chain and lipids in mitochondrial membranes.
It also occurred to him that mitochondria might be an ideal target for intervening in the aging process...
...Acetyl-L-carnitine, also known as Alcar, is a nutrient that helps transport fatty-acid fuel across lipid membranes into mitochondria. Thus the more Alcar a cell has, the better its mitochondria might function.
Ames reasoned that high levels of Alcar might also combat the problems of aging membranes and decrepit enzymes. He began feeding Alcar to his old rats. Within weeks, he and Hagen noticed improvements in the animals' biochemistry and behavior. Their mitochondria were going full bore again, and they had become far more active. But the old rats were still churning out oxidants at a very high rate. In fact, by goosing metabolism, Alcar seemed to slightly increase free-radical production. "We didn't solve the problem of oxidants," Ames says. "In fact, if anything, it was a little worse."
Ames decided to add an agent to the rats' diet to neutralize the oxidants. He tried lipoic acid, a mitochondrial antioxidant. The results were profound. Oxidants and oxidative damage to mitochondrial components dropped dramatically. Both the structure and function of the mitochondria improved. The rats' activity levels doubled. They were, Ames says, "doing the Macarena." The combination of the nutrient and the antioxidant had a synergistic effect. "The two together are better than either one alone."
http://www.discover.com/oct_02/featradical.html
Mitochondria targeting antioxidants:
ALCAR
Lipoic Acid
Also, COQ10 is a myocardial mitochondria free radical scavenger, which is probably not a bad antioxidant to consider on DNP.
I am just curious to see if people think that this might be a good approach to choosing antioxidants on a DNP cycle. I really don't know much about antioxidants- this post was basically a half an hour worth of googleing. And sorry that most of the sources are not "primary sources," I am just throwing out ideas here.
The next important factors would be:
Price
Dosing
Strength/Bioavailability
Synergism/interactions
Tissue specificity
..and I'm probably missing a lot here.. I thought this could be a start, though.
