nipple pain from nolva?

[bg65]

I have never had gyno probs before, and I am running a low dose 500mg/wk enanthate with 500mg/wk EQ and fronting with 100mg prop EOD...so that's about 850mg test/wk right now, and I am taking 2mg/day femara...I am in wk three and I noticed my nipps were getting a little puffy, but no itching or anything...I have always had anti-e's on hand, but never needed them during cycles and only used clomid for pct...so after 4 cycles I have never used nolva...anyways, I started taking 20mg/day and the first day my nipples hurt like crazy, I continued 20mg/day for three days with the pain not resolving, so I stopped the nolva and the irritation went away...my nipps are still a little puffy, but they don't hurt... I got the nolva (from IP) from a good bro and he has had no probs with it...have any of you guys ever had this happen? I thought that I wouldn't have any e probs with the femara, especially at the doses I am taking...I do not have any water retention or hypertension, so I don't think estrogen is that high... I don't know, any advice or input would be appreciated
thanks

[Heretic]

I think puffy nips are more a sign of water retention or maybe even fat gain, but itchy/painful nips or hard lumps are definitely a sign of gyno starting. Are you retaining water at all anywhere else?
Regards,
-H-

[mrpg13]

I don't want to get into a debate about IP's products, but if I were you I would pick up some Pharm grade, or generic nolvadex. If you are getting gyno, I wouldn't want to rely on IP's products to get rid of something as serious as gyno..JMO

[graybass]

Probally what happened is that your nips kept getting worse from the Est, not the nolva. It takes a few days for the Nolva to kick in, so just as it started working you stopped it. which is ok because I usually stop the nolva after it starts working anyway.

Maybe, maybe not. Just a thought.
GB

[bg65]

graybass- I thought that maybe the pain was just the nolva starting to work or whatever, but I have not had the irritation since I stopped the nolva, just the puffy nipps...
H- I don't have any water retention anywhere, which means I am using good Femara , also I am actually tightening up, not gaining fat...
do you guys think that it is at all possible that the e-receptors in my nipples are sensitive to nolva? Although weak, it is still an estrogen, right? I have asked a lot of my friends that have experience and they have never heard of nolva causing irritation, I also though about what mrpg13 said, IP doesn't have a sparkling rep...It's frustrating, I am actually very educated when it comes to the human body and I have a very good understanding of the mechanisms of action of hormones in the body, and I can't figure this out...maybe I should just try the nolva for a week and see if the pain goes away? thanks for the input

[MaxRep]

Nolvadex is an estrogen? Where did you hear that? Nolvadex is in the class of drugs known as SERM's and is an estrogen antagonist in breast tissue and an estrogen agonist in other tissue. I suppose nolvadex being an estrogen agonist in some tissues could mislead some people who mistake "like estrogen" for estrogen?

If you have a good understanding of how hormones work then you should know nolvadex couldn't be the cause of any nipple puffyness or irritation.

Since you're using IP's garbage, I would wonder if you're even taking nolvadex.

You may find the following of interest.

Good luck,
MaxRep

__________________________________________________ _____

Pharmacology

Tamoxifen citrate, a nonsteroidal antiestrogen, is a triphenylethylene derivative with both estrogen antagonist (antiestrogen) and agonist (estrogen-like) activity. Tamoxifen acts as an estrogen antagonist on breast tissue and in the CNS and as an estrogen agonist on endometrium, bone, and lipids. The precise mechanism(s) of action of the drug is not known. Tamoxifen and at least several of its metabolites compete with estradiol for binding to cytoplasmic estrogen receptors in tissues such as breast, uterus, vagina, anterior pituitary, and tumors containing high concentrations of estrogen receptors.

•Effects on the Breast

The competition of tamoxifen and at least several of its metabolites with estradiol for binding to cytoplasmic estrogen receptors in breast tissue is thought to contribute to its protective effect against the development of breast cancer. Although the tamoxifen-receptor and metabolite-receptor complexes are translocated to the nucleus, binding to nuclear chromatin appears to occur in an atypical manner and persists for longer periods of time than the estrogen-receptor complexes. DNA synthesis and estrogen responses are thus markedly reduced. Contrary to a previous hypothesis, a study in rats demonstrated that tamoxifen does not interfere with replenishment of cytoplasmic estrogen receptors. The in vivo antiestrogenic and antitumor effects of tamoxifen appear to result from the combined actions of unchanged drug and several of the identified metabolites, but their relative contribution remains to be fully elucidated.

Tamoxifen also appears to oppose the proliferative effects of estrogen on breast epithelium by increasing production of inhibitory factors (e.g., transforming growth factor [TGF]-β ) and decreasing production of stimulatory factors (e.g., TGF-α, insulin-like growth factor-1) that influence breast cell growth.