receptors question!!

[Mind]

hi guys

a few days ago I emailed mr. Anthony Roberts asking him about how to fresh up my receptors after a cycle, he answered me that it's just an old myth.

right now i'm on week 7 , Deca + Test E.

500 test
375 deca

my last cycle was NPP + sustanon.
I finished it 4 months ago.

right now i don't notice any changes yet from my deca+test cycle.
if receptor downregulation is just a myth why don't I notice anything from my cycle?

[jasthace]

Receptor down regulation is not an issue with AAS,the issue is your body achieving homeostasis by increasing production of cortisol to balance the anabolic effect.
I think this is the main theory behind the tapering cycle system,so you are increasing the dose {keeping ahead of homeostasis} then decreasing the dose ,so's not to be left with majorly elevated cortisone levels post cycle.
There are better ways to combat it now, you merely have to though more drugs at the problem

As for your gear and no noticable effects yet?

[Mind]

nothing noticable yet!!!

shall I stop? or increase the dose?

[Mind]

more opinions?

[Conciliator]

Originally Posted by jasthace

Receptor down regulation is not an issue with AAS,the issue is your body achieving homeostasis by increasing production of cortisol to balance the anabolic effect.

What do you base this statement on? I don't think anyone knows for sure what causes the functional loss that's seen after several weeks of AAS administration.

[shreddedwheat]

Have you considered that your gear might be fake? After 7 weeks at those dosages you should definitely be noticing changes. How's your libido?

[jasthace]

Originally Posted by Conciliator

What do you base this statement on? I don't think anyone knows for sure what causes the functional loss that's seen after several weeks of AAS administration.

Regarding Androgen Receptor downregulation

Part One
Introduction to Anabolic Steroids by Bill Roberts
Part Two
Androgen Receptor Regulation by Bill Roberts

Regarding Homeostasis

Regulation of hormone production is under homeostatic control

Food and Fitness: homeostasis
The maintenance of a constant physical or chemical state. Many processes in the body are under homeostatic control: deviations of output from a normal level (set point or norm) activate corrective mechanisms to bring the level back to normal.

Temperature regulation is an example of a homeostatic mechanism. The usual set point for the core temperature is 37 degrees Celsius (37°C): body temperatures above this norm result in sweating and an increase in blood flow to the skin to cool the body; low body temperatures result in an increase in basal metabolic rate (more fuel is burnt by the liver) and shivering to generate heat.

Other, homeostatic mechanisms include those controlling blood glucose levels, blood acidity, and hormone secretions. There are also suggestions that percentage fat composition and body weight have similar control systems (see adipostat and set point theory).

Every cell is capable of producing a vast number of regulatory molecules. The classical endocrine glands and their hormone products are specialized to serve regulation on the overall organism level, but can in many instances be used in other ways or only on the tissue level.

The rate of production of a given hormone is most commonly regulated by a homeostatic control system, generally by negative feedback. Homeostatic regulation of hormones depends, apart from production, on the metabolism and excretion of hormones.

Hormone secretion can be stimulated and inhibited by:

Other hormones (stimulating or releasing-hormones)
Plasma concentrations of ions or nutrients, as well as binding globulins
Neurons and mental activity
Environmental changes, e.g. of light or temperature
One special group of hormones are trophic hormones that act as stimulants of hormone production of other endocrine glands. For example: thyroid-stimulating hormone (TSH) causes growth and increased activity of another endocrine gland - the thyroid - hence increasing output of thyroid hormones.

A recently identified and studied class of hormones is that of the "Hunger Hormones" - ghrelin, orexin and PYY 3-36 - and their antagonists - e.g. leptin.


.

[BBC3]

NICE STUFF!!!

Originally Posted by jasthace

Regarding Androgen Receptor downregulation

Part One
Introduction to Anabolic Steroids by Bill Roberts
Part Two
Androgen Receptor Regulation by Bill Roberts

Regarding Homeostasis

Regulation of hormone production is under homeostatic control

Food and Fitness: homeostasis
The maintenance of a constant physical or chemical state. Many processes in the body are under homeostatic control: deviations of output from a normal level (set point or norm) activate corrective mechanisms to bring the level back to normal.

Temperature regulation is an example of a homeostatic mechanism. The usual set point for the core temperature is 37 degrees Celsius (37°C): body temperatures above this norm result in sweating and an increase in blood flow to the skin to cool the body; low body temperatures result in an increase in basal metabolic rate (more fuel is burnt by the liver) and shivering to generate heat.

Other, homeostatic mechanisms include those controlling blood glucose levels, blood acidity, and hormone secretions. There are also suggestions that percentage fat composition and body weight have similar control systems (see adipostat and set point theory).

Every cell is capable of producing a vast number of regulatory molecules. The classical endocrine glands and their hormone products are specialized to serve regulation on the overall organism level, but can in many instances be used in other ways or only on the tissue level.

The rate of production of a given hormone is most commonly regulated by a homeostatic control system, generally by negative feedback. Homeostatic regulation of hormones depends, apart from production, on the metabolism and excretion of hormones.

Hormone secretion can be stimulated and inhibited by:

Other hormones (stimulating or releasing-hormones)
Plasma concentrations of ions or nutrients, as well as binding globulins
Neurons and mental activity
Environmental changes, e.g. of light or temperature
One special group of hormones are trophic hormones that act as stimulants of hormone production of other endocrine glands. For example: thyroid-stimulating hormone (TSH) causes growth and increased activity of another endocrine gland - the thyroid - hence increasing output of thyroid hormones.

A recently identified and studied class of hormones is that of the "Hunger Hormones" - ghrelin, orexin and PYY 3-36 - and their antagonists - e.g. leptin.


.

[Fraggle]

I believe one of the primary reasons we see a decrease in the effects of AAS over time is due to the increase in sex-hormone binding globulin. With continued high levels of hormones, the body will attempt to counter with higher levels of SHBG. Any testosterone (or variants) bound with SHBG is considered tightly bound and has no effect within the cell. The lightly bound hormones (usually to albumin) is still capable of some effect in the body. So while action at the receptor is unlikely to be 'down regulated', you are still going to notice a decrease in the effects with time. Also remember that your body only wants to grow as fast as it needs to. AAS shifts the balance favorably in the direction of growth, but it is going to get steadily more difficult to add mass and strength at the speed seen during the initial stages of a cycle.

Fraggle

[Mind]

thanks guys

my libido is normal, and my gear is 100% real. i'm pretty sure about it.

i'll stop this cycle. take a long period off then I'll start again with other stuff than deca. EQ or Tren E maybe!

[Conciliator]

Originally Posted by jasthace

Regarding Androgen Receptor downregulation.

You didn't answer the question. Obviously, the body gravitates towards homeostasis. There's clearly a functional loss. But why? I'm asking what basis you have for saying that increased production of cortisol is the culprit.

[Mind]

thanx guys

I still don't understand, why didn't I get any results?

[Mind]

bump

[BBC3]

Originally Posted by Mind

thanx guys

I still don't understand, why didn't I get any results?

Take it from someone who just had a BAD experience with gear that was not as advertised. I think anyone will agree that 500mg of test is enough to light you up after seven weeks. Not to mention the Deca...... It seems like my first cycle of test felt slow all the way to week seven. And I even had a couple of 800 mg weeks in there to kick it up cause I felt the same. A lot of these guys around here agree that "loading" with 1000mg of test in first few weeks is a good way to get started (in leu of dbol or something that I refer to as crude). If you stick with the 500 mg, you will certainly be feeling it two more weeks tops. Personally, I like to find my threshold with large doses (800-1000mg) and level off from there. 500mg will be plenty once you are "going". I would recommend pinning a couple a 800mg test weeks and you should find what you are looking for, then back down to 500-600mg /wk. I also found that you should plan on 16 to 24 week cycle with test to get good results. If you can go 24 weeks, I would drop the Deca totally out at week 16 as it has a long half life and you will be shut down for some time over that. Your test should hold you the rest of the way at 6-800mg/wk once you are there. That way you can still get a good 8 weeks with the deca. I would even consider staying on the test for weeks 25-28 to try to get further through the deca half-life. My guess is that if you simply go 12-16 weeks you will not get enough time to build, and you will come off and be another one complaining about being shut down 3-4 months down the road. Way better to ride the test extended than to PCT for the deca (my opinion). split up a 5000iu of HCG every 4-6 weeks from here on should be good for quick recovery if you close out with test only as listed above.
Go ahead and pin a couple of 800mg test weeks. If you are not there after that, you should consider your source.