receptors question!!

[Mind]

hi guys

a few days ago I emailed mr. Anthony Roberts asking him about how to fresh up my receptors after a cycle, he answered me that it's just an old myth.

right now i'm on week 7 , Deca + Test E.

500 test
375 deca

my last cycle was NPP + sustanon.
I finished it 4 months ago.

right now i don't notice any changes yet from my deca+test cycle.
if receptor downregulation is just a myth why don't I notice anything from my cycle?

[jasthace]

Receptor down regulation is not an issue with AAS,the issue is your body achieving homeostasis by increasing production of cortisol to balance the anabolic effect.
I think this is the main theory behind the tapering cycle system,so you are increasing the dose {keeping ahead of homeostasis} then decreasing the dose ,so's not to be left with majorly elevated cortisone levels post cycle.
There are better ways to combat it now, you merely have to though more drugs at the problem

As for your gear and no noticable effects yet?

[Mind]

nothing noticable yet!!!

shall I stop? or increase the dose?

[Mind]

more opinions?

[Conciliator]

Originally Posted by jasthace

Receptor down regulation is not an issue with AAS,the issue is your body achieving homeostasis by increasing production of cortisol to balance the anabolic effect.

What do you base this statement on? I don't think anyone knows for sure what causes the functional loss that's seen after several weeks of AAS administration.

[shreddedwheat]

Have you considered that your gear might be fake? After 7 weeks at those dosages you should definitely be noticing changes. How's your libido?

[jasthace]

Originally Posted by Conciliator

What do you base this statement on? I don't think anyone knows for sure what causes the functional loss that's seen after several weeks of AAS administration.

Regarding Androgen Receptor downregulation

Part One
Introduction to Anabolic Steroids by Bill Roberts
Part Two
Androgen Receptor Regulation by Bill Roberts

Regarding Homeostasis

Regulation of hormone production is under homeostatic control

Food and Fitness: homeostasis
The maintenance of a constant physical or chemical state. Many processes in the body are under homeostatic control: deviations of output from a normal level (set point or norm) activate corrective mechanisms to bring the level back to normal.

Temperature regulation is an example of a homeostatic mechanism. The usual set point for the core temperature is 37 degrees Celsius (37°C): body temperatures above this norm result in sweating and an increase in blood flow to the skin to cool the body; low body temperatures result in an increase in basal metabolic rate (more fuel is burnt by the liver) and shivering to generate heat.

Other, homeostatic mechanisms include those controlling blood glucose levels, blood acidity, and hormone secretions. There are also suggestions that percentage fat composition and body weight have similar control systems (see adipostat and set point theory).

Every cell is capable of producing a vast number of regulatory molecules. The classical endocrine glands and their hormone products are specialized to serve regulation on the overall organism level, but can in many instances be used in other ways or only on the tissue level.

The rate of production of a given hormone is most commonly regulated by a homeostatic control system, generally by negative feedback. Homeostatic regulation of hormones depends, apart from production, on the metabolism and excretion of hormones.

Hormone secretion can be stimulated and inhibited by:

Other hormones (stimulating or releasing-hormones)
Plasma concentrations of ions or nutrients, as well as binding globulins
Neurons and mental activity
Environmental changes, e.g. of light or temperature
One special group of hormones are trophic hormones that act as stimulants of hormone production of other endocrine glands. For example: thyroid-stimulating hormone (TSH) causes growth and increased activity of another endocrine gland - the thyroid - hence increasing output of thyroid hormones.

A recently identified and studied class of hormones is that of the "Hunger Hormones" - ghrelin, orexin and PYY 3-36 - and their antagonists - e.g. leptin.


.

[BBC3]

NICE STUFF!!!

Originally Posted by jasthace

Regarding Androgen Receptor downregulation

Part One
Introduction to Anabolic Steroids by Bill Roberts
Part Two
Androgen Receptor Regulation by Bill Roberts

Regarding Homeostasis

Regulation of hormone production is under homeostatic control

Food and Fitness: homeostasis
The maintenance of a constant physical or chemical state. Many processes in the body are under homeostatic control: deviations of output from a normal level (set point or norm) activate corrective mechanisms to bring the level back to normal.

Temperature regulation is an example of a homeostatic mechanism. The usual set point for the core temperature is 37 degrees Celsius (37°C): body temperatures above this norm result in sweating and an increase in blood flow to the skin to cool the body; low body temperatures result in an increase in basal metabolic rate (more fuel is burnt by the liver) and shivering to generate heat.

Other, homeostatic mechanisms include those controlling blood glucose levels, blood acidity, and hormone secretions. There are also suggestions that percentage fat composition and body weight have similar control systems (see adipostat and set point theory).

Every cell is capable of producing a vast number of regulatory molecules. The classical endocrine glands and their hormone products are specialized to serve regulation on the overall organism level, but can in many instances be used in other ways or only on the tissue level.

The rate of production of a given hormone is most commonly regulated by a homeostatic control system, generally by negative feedback. Homeostatic regulation of hormones depends, apart from production, on the metabolism and excretion of hormones.

Hormone secretion can be stimulated and inhibited by:

Other hormones (stimulating or releasing-hormones)
Plasma concentrations of ions or nutrients, as well as binding globulins
Neurons and mental activity
Environmental changes, e.g. of light or temperature
One special group of hormones are trophic hormones that act as stimulants of hormone production of other endocrine glands. For example: thyroid-stimulating hormone (TSH) causes growth and increased activity of another endocrine gland - the thyroid - hence increasing output of thyroid hormones.

A recently identified and studied class of hormones is that of the "Hunger Hormones" - ghrelin, orexin and PYY 3-36 - and their antagonists - e.g. leptin.


.

[Fraggle]

I believe one of the primary reasons we see a decrease in the effects of AAS over time is due to the increase in sex-hormone binding globulin. With continued high levels of hormones, the body will attempt to counter with higher levels of SHBG. Any testosterone (or variants) bound with SHBG is considered tightly bound and has no effect within the cell. The lightly bound hormones (usually to albumin) is still capable of some effect in the body. So while action at the receptor is unlikely to be 'down regulated', you are still going to notice a decrease in the effects with time. Also remember that your body only wants to grow as fast as it needs to. AAS shifts the balance favorably in the direction of growth, but it is going to get steadily more difficult to add mass and strength at the speed seen during the initial stages of a cycle.

Fraggle

[Mind]

thanks guys

my libido is normal, and my gear is 100% real. i'm pretty sure about it.

i'll stop this cycle. take a long period off then I'll start again with other stuff than deca. EQ or Tren E maybe!