Revolutionary? Reverse T Negative feedback

[Jtay]

Could this old drug find be revolutionary to bodybuilding and anti-aging medicine?

http://endo.endojournals.org/cgi/con...ll/141/11/3940

What exactly is Baclofen:

http://en.wikipedia.org/wiki/Baclofen

Yes, I know, the study was referring to intrathecal Baclofen. However, Baclofen is available in pill form for a very low cost of around .20 - .40 per tablet...very cheap! Here in the USA named Lioresal.

Ok, so does the pill form cross the BBB:

http://www.ncbi.nlm.nih.gov/sites/en...t=AbstractPlus

The only hitch, I can't find any human studies. Anyone here tried it in their program in lieu of HCG?

Man, if this works in humans and eliminates the T Negative feedback this will be BIG NEWS.

My doctor will easily prescribe it because it is considered to be a "safe" drug. Just told him my muscles were stiff .

Also, wrote to Swale to get his thoughts.

If this is old news sorry as I don't have much time to monitor/research this board. However, I don't think it is widely known yet. If anyone tries it be sure to report your results. I'm under the impression that the Baclofen muscle relax characteristics counterbalances the T aggressiveness thus, you can increase T and still have the euphoria and build mass without the desire to kill - Lol!

Comments?

[jasthace]

Interesting,
Here's another readily available muscle relaxant that has positive effects

Amitriptyline/Nortriptyline

The tricyclic antidepressant Amitriptyline/Nortriptyline (AMT) and the calcium channel blocker flunarizine are frequently used in the preventive treatment of migraine, but the side-effect of prominent weight gain that frequently emerges during preventive treatment of migraine with these agents often leads to the discontinuation of therapy. In this study, we aimed to investigate the possible relationship between the weight gain associated with the use of these agents and serum levels of leptin, C-peptide and insulin in patient with migraine. Forty-nine migraine patients with a body mass index (BMI) < 25 and without any endocrinological, immunological or chronic diseases were randomly divided into two groups, receiving AMT or flunarizine. There was a statistically significant increase in serum levels of leptin, C-peptide, insulin and measures of BMI in both groups when measured at the 12th week of therapy compared to their respective basal levels. To our knowledge this is the first study investigating the effects of AMT and flunarizine on serum leptin levels in preventive use of migraine treatment. A result from this study indicates that AMT and flunarizine may cause leptin resistance possibly by different mechanisms and thereby result in increase in serum leptin levels and BMI.

This article is cited by:
Paola Sarchielli, Maria Luisa Mancini, Paolo Calabresi. (2006) Practical Considerations for the Treatment of Elderly Patients with Migraine. Drugs & Aging 23:6, 461

Leptin appears to be a significant regulator of reproductive function. These effects are probably due in part to the ability of leptin to enhance secretion of gonadotropin-releasing hormone, and thus luteinizing and follicle-stimulating hormones from the anterior pituitary.

Leptin- http://www.vivo.colostate.edu/hbooks...ht/leptin.html

C-peptide- http://ajpendo.physiology.org/cgi/co...ull/285/4/E864

In summary, proinsulin C-peptide stimulates MAPK in fibroblasts through a common or similar pathway to that for NPY, which requires PKC, PI-3K and PTX-sensitive G-protein.

MAPK- http://en.wikipedia.org/wiki/Mitogen...protein_kinase

To date, four distinct groups of MAPKs have been characterized in mammals:

extracellular signal-regulated kinases (ERKs). The ERKs (also known as classical MAP kinases) signaling pathway is preferentially activated in response to growth factors and phorbol ester (a tumor promoter), and regulates cell proliferation and cell differentiation.
c-Jun N-terminal kinases (JNKs), also known as stress-activated protein kinases (SAPKs).
p38 isoforms. Both JNK and p38 signaling pathways are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation and apoptosis.
ERK5. ERK5, which has been found recently, is activated both by growth factors and by stress stimuli, and it participates in cell proliferation.

[Jtay]

The news just seems to be getting better and better:

Also looks like Baclofen raises IGF-I and it appears this study was with the pills. Ok, let me see,,,,so it raises LH, FSH, Testosterone, IGF-I naturally and you can also use testosterone with no negative feedback and all this for pennies a pill. Someone help me here.....Am I dreaming or what?

Here is another study....

And there are more

http://jcp.sagepub.com/cgi/content/abstract/46/4/476

[Jtay]

Until further notice, I will report on Baclofen over on the "Mens Health Forum" under the same heading as here.