wtf, why people talk about receptors shutting off?

[joshbuffed2002]

i read something a while back that said there is no scientific proof that receptors shut down when using a particular test, i got a friend in the gym, he is strong and knows alot of what he is doing but i think like some or all of us had been misled at one time about receptors shutting down, he says i should change up my test every 3 weeks or my receptors shut down and im wasting my shit, like go 3 weeks of enan, and then start on cyp. i think the receptor thing is all bullshit from what ive read. i was thinking combining different test would do great cause of the mixture, but why do people still believe the receptor shutting down myth? if what i read says there is no scientific proof that receptors shut down after doing a certain drug for a period of time, how the hell did that myth come about? its not like im a scientist and know for sure if its true or not, i just want to know what everybody else thinks or knows.

[C A]

Originally Posted by joshbuffed2002

i read something a while back that said there is no scientific proof that receptors shut down when using a particular test, i got a friend in the gym, he is strong and knows alot of what he is doing but i think like some or all of us had been misled at one time about receptors shutting down, he says i should change up my test every 3 weeks or my receptors shut down and im wasting my shit, like go 3 weeks of enan, and then start on cyp. i think the receptor thing is all bullshit from what ive read. i was thinking combining different test would do great cause of the mixture, but why do people still believe the receptor shutting down myth? if what i read says there is no scientific proof that receptors shut down after doing a certain drug for a period of time, how the hell did that myth come about? its not like im a scientist and know for sure if its true or not, i just want to know what everybody else thinks or knows.

They're stupid. Receptors don't respond to the ester. Your friends don't know anything about chemistry or physiology.

[VDC]

Well theres many misinformed notions concerning aas,,,Receptors never shut down,,,Everyday they're responding to natural Test and they don't shut down,,,The ester has no effect on this either,,,The ester only affects the amount of time the aas will be in the system,,,VDC

[joshbuffed2002]

i feel like an idiot asking this, but i dont know so im gonna ask anyway, what is aas?

[MaxRep]

Originally Posted by joshbuffed2002

i feel like an idiot asking this, but i dont know so im gonna ask anyway, what is aas?

Everyone above is correct, there's no such thing as receptor shutdown. Not only is there no scientific proof of such a notion, there is scientific proof that it does not occur. You may want to suggest to your friend that he do a little research on the matter and get his facts straight.

AAS= Anabolic/Androgenic Steroid

MaxRep

[liftheavy54]

MaxRep you were very nice to answer that question politely.

[MaxRep]

Originally Posted by liftheavy54

MaxRep you were very nice to answer that question politely.

It's part of my new personal policy of trying to be more tolerant of people new to the game.

We all start somewhere but we may need to put up a sticky telling newbies to start with the search feature...

MaxRep

[vascu]

I hear ya Max!! It is sometimes tuff to listen to things that are just off the wall but we all have to realize that not everyone has been around it as long as some of us.

vascu

[onamission]

Originally Posted by MaxRep

It's part of my new personal policy of trying to be more tolerant of people new to the game.

We all start somewhere but we may need to put up a sticky telling newbies to start with the search feature...

MaxRep

I think in a few months the sticky about the search feature will be a good idea, but right now I dont think there's enough info on this board to warrant it. So for now I think we're all going to have to put up with newbie type questions and anwser them as nicely as possible.

[Hogg]

Its a good time to remind everyone about receptor counts and the relationship with the mineral zinc in one's diet. There is a relationship between these two items and I believe that alcohol can also affect receptor count......didnt we cover that in my multi page cut and paste from medline on the old board???? Perhaps this is an item that someone with time on their hands can research........the bottom line, diet and the effectiveness of androgens are related - if you're not getting enough zinc in your diet, its time to supplement.


Man, this is starting to bug me..... I'd swear that there was a serious correlation between alcohol, zinc, and receptor counts because I remember researching the hell out of his relationship and advising a younger ( 4 night a week drinker) colleague of mine at the office to go buy a bottle of zinc at GNC......like I said, this is a good research exercise for someone who finds it interesting.

[Hogg]

This is not exactly what I was looking for but it cites references to other studies

http://www.musclephotos.com/zinc.html

[MaxRep]

I believe hogg is correct about there being a correlation between zinc and androgen receptor sites.

However, before you all start downing mega doses of zinc, a little is good, a lot is not. There is some concern over high zinc dosages and prostate cancer. You can review the following abstract and do some follow up study on your own.

MaxRep

__________________________________________________ ______________

J Natl Cancer Inst. 2003 Jul 2;95(13):1004-7.

Comment in:
J Natl Cancer Inst. 2003 Oct 15;95(20):1556; author reply 1556-7.

Zinc supplement use and risk of prostate cancer.

Leitzmann MF, Stampfer MJ, Wu K, Colditz GA, Willett WC, Giovannucci EL.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. leitzmann@mail.nih.gov

The high concentration of zinc in the prostate suggests that zinc may play a role in prostate health. We examined the association between supplemental zinc intake and prostate cancer risk among 46,974 U.S. men participating in the Health Professionals Follow-Up Study. During 14 years of follow-up from 1986 through 2000, 2901 new cases of prostate cancer were ascertained, of which 434 cases were diagnosed as advanced cancer. Supplemental zinc intake at doses of up to 100 mg/day was not associated with prostate cancer risk.

However, compared with nonusers, men who consumed more than 100 mg/day of supplemental zinc had a relative risk of advanced prostate cancer of 2.29 (95% confidence interval = 1.06 to 4.95; P(trend) =.003), and men who took supplemental zinc for 10 or more years had a relative risk of 2.37 (95% confidence interval = 1.42 to 3.95; P(trend)<.001).

Although we cannot rule out residual confounding by supplemental calcium intake or some unmeasured correlate of zinc supplement use, our findings, that chronic zinc oversupply may play a role in prostate carcinogenesis, warrant further investigation.

__________________________________________________ ____________

[Starkraven]

never knew about zinc like that, and ive got some at home. if one were to start supplementing, what is a good dose to take everyday? would this reduce water retention whether you are on juice or not? how strong would you say it is preventing estrogen in the body compared to arimidex/femara?

Originally Posted by MaxRep

I believe hogg is correct about there being a correlation between zinc and androgen receptor sites.

However, before you all start downing mega doses of zinc, a little is good, a lot is not. There is some concern over high zinc dosages and prostate cancer. You can review the following abstract and do some follow up study on your own.

MaxRep

__________________________________________________ ______________

J Natl Cancer Inst. 2003 Jul 2;95(13):1004-7.

Comment in:
J Natl Cancer Inst. 2003 Oct 15;95(20):1556; author reply 1556-7.

Zinc supplement use and risk of prostate cancer.

Leitzmann MF, Stampfer MJ, Wu K, Colditz GA, Willett WC, Giovannucci EL.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. leitzmann@mail.nih.gov

The high concentration of zinc in the prostate suggests that zinc may play a role in prostate health. We examined the association between supplemental zinc intake and prostate cancer risk among 46,974 U.S. men participating in the Health Professionals Follow-Up Study. During 14 years of follow-up from 1986 through 2000, 2901 new cases of prostate cancer were ascertained, of which 434 cases were diagnosed as advanced cancer. Supplemental zinc intake at doses of up to 100 mg/day was not associated with prostate cancer risk.

However, compared with nonusers, men who consumed more than 100 mg/day of supplemental zinc had a relative risk of advanced prostate cancer of 2.29 (95% confidence interval = 1.06 to 4.95; P(trend) =.003), and men who took supplemental zinc for 10 or more years had a relative risk of 2.37 (95% confidence interval = 1.42 to 3.95; P(trend)<.001).

Although we cannot rule out residual confounding by supplemental calcium intake or some unmeasured correlate of zinc supplement use, our findings, that chronic zinc oversupply may play a role in prostate carcinogenesis, warrant further investigation.

__________________________________________________ ____________

[MaxRep]

Originally Posted by Starkraven

never knew about zinc like that, and ive got some at home. if one were to start supplementing, what is a good dose to take everyday? would this reduce water retention whether you are on juice or not? how strong would you say it is preventing estrogen in the body compared to arimidex/femara?

I'm not sure how you came up with a correlation between zinc and estrogen prevention. A while back, I recall reading a study where there was a positive correlation between zinc and the number of androgen receptor sites. I believe this is what Hogg was alluding to. The abstract on the study I just posted was regarding the correlation between excessive amounts of zinc and prostate cancer. For anyone supplementing zinc, it would appear any amount less than 100mg/day is fine as regards the prostate cancer issue and the same amount could help to optimize your number of androgen receptor sites.

MaxRep

[joshbuffed2002]

i reckon i should have been able to guess what aas meant, i never heard it abreviated that way, i am a newbie on meso but im not a newbie in the gym or doing cycles, i just found this website that a friend of mine goes to alot and he said i can learn alot in detail about what ive been doing by coming in here. if i have aggravating questions i appreciate the ones that answer it, i dont care if the answers are nice or not, i just want the truth. thanx